Langerhans cell histiocytosis

Langerhans' cell histiocytosis (LCH), also known as Langerhans-cell granulomatosis, is a Langerhans cell proliferative disease that invades the skin and outside the skin. Organs. The disease can affect the skin, bones, lungs, nervous system and other organs. It can be divided into 3 types clinically: Letterer-siwe disease, Hand-schüller-christian disease and eosinophilic granuloma. But there is no obvious boundary between the three, and they can often overlap or transform each other. Generally speaking, if the disease occurs within one year of age, it is often characterized by fatal visceral damage, mostly Letterer-siwe disease. If it occurs in childhood, it is usually multiple bone damage, while the visceral damage is mild, namely Hand -schüller-christian disease; in older children and adults, the disease is usually localized and often manifests as one or more bone lesions, namely eosinophilic granuloma.

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