Senile acute leukemia

Elderly leukemias have different definitions. Generally, leukemia patients who are over 60 years old are the same as other age group leukemias. It is a malignant disease of unknown origin due to hematopoietic stem cells. The incidence of adult acute leukemia (ALL) gradually decreases with age. The annual incidence of ALL in the elderly is about 1 in 100,000; AML is rare in young people, and the incidence increases exponentially after the age of 40. The median age of onset is about 64 years. The biological characteristics of senile acute leukemia are mainly that the general condition of most patients is poor, and those with important organ diseases such as heart, liver, and kidney are more common. About 30% of patients have a history of MDS before the onset of leukemia, and leukemia often involves earlier stages. Hematopoietic stem cells are often accompanied by cytogenetic abnormalities with poor prognosis, and often have high expression of MDR1 and P-gp.