Histidine

Histidine is the basic unit of protein and is one of the 21 amino acids that make up human proteins. The amino acids are all amino acids except the amino acids. The amino acids constituting the protein molecule are all L-amino acids, but in recent years it has been confirmed that they can be isomeric as D-amino acids, and the specific mechanism has not been studied. When the histidine of the blood reaches 0.5mmol/L, histidine excretes the imidazolium pyruvate into the urine under the action of transaminase, and the urine chlorinated high-iron test can be positive. The histidine load test is performed on the patient, and no uric acid or azole is observed. The excretion of iminomethyl glutamate propionate is increased, but the ratio of histidine-degrading enzyme to histase is abnormal. The blood is rich in glutamine and glutamic acid, and the blood concentration of serotonin is decreased. The disease is autosomal recessive. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. The alcohol content in the blood directly affects the test results. Normal value 33.76 to 66.36 μmol/L. Clinical significance Increased in histidine. Patients with histidine have moderate mental retardation and language development retardation. When the histidine of the blood reaches 0.5mmol/L, histidine excretes the imidazolium pyruvate into the urine under the action of transaminase, and the urine chlorinated high-iron test can be positive. The histidine load test is performed on the patient, and no uric acid or azole is observed. The excretion of iminomethyl glutamate propionate is increased, but the ratio of histidine-degrading enzyme to histase is abnormal. The blood is rich in glutamine and glutamic acid, and the blood concentration of serotonin is decreased. The disease is autosomal recessive. High results may be diseases: folic acid deficiency, megaloblastic anemia considerations 1. The plasma amino acid concentration of normal people fluctuates day and night, with a peak at 8 to 10 in the morning and a trough at midnight. When taking blood, it is necessary to avoid the effects of digestion and absorption of food. It is better to take blood on an empty stomach in the morning. 2. If the specimen is not suitable for hemolysis, it may lead to a false increase in the measurement results. Inspection process Immediately after venous blood collection, the test was performed by an amino acid automatic analyzer. Not suitable for the crowd Inappropriate people: Generally there are no people who are not suitable. Adverse reactions and risks 1. Infection: Pay attention to aseptic operation when collecting blood, avoid contamination of water and other parts at the blood collection site to avoid local infection. 2, bleeding: after the blood is given a full compression time, especially coagulopathy, bleeding tendency, to avoid local subcutaneous oozing, bruising and swelling.