Plasminogen activity (PLG,A)

Plasminogen is a single-chain glycoprotein that is synthesized in the liver and is present in plasma. Its main function is to cleave plasmin in arginine and proline under the action of various plasminogen activators, to cleave fibrin (original) and partial coagulation factors, some adhesion proteins and Degrade and dissolve the fibrin clot. Secondary fibrotic diseases, such as placenta previa, early placental stripping, amniotic fluid embolism, malignant tumor, leukemia, cirrhosis, severe hepatitis, portal hypertension, and hepatectomy. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value 0.75 to 1.40. (chromogenic substrate method). 230 to 340 mg/L. (Immuno-diffusion method). Clinical significance Lowering indicates increased fibrinolytic properties, as seen in 1, primary fibrinolysis disease, such as congenital plasminogen deficiency. 2, secondary fibrotic diseases, such as placenta previa, early placental stripping, amniotic fluid embolism, malignant tumor, leukemia, cirrhosis, severe hepatitis, portal hypertension, hepatectomy after surgery. Elevation suggests a decrease in fibrinolysis, seen in prethrombotic states and thrombotic diseases. Low results may be diseases: leukemia, cirrhosis precautions It is forbidden to take anticoagulants, such as aspirin, before the test. Inspection process Determination of activity by chromogenic substrate method Principle: Due to the action of streptokinase, plasminogen is completely converted to plasminogen activator (streptokinase-plasminogen complex) in plasma samples. The complex then hydrolyzes the chromogenic substrate and is measured by a spectrophotometer. The increase in absorbance is directly proportional to the plasminogen activity. Immunochemical method Gel electrophoresis, immunoturbidimetry, radioimmunoassay. Not suitable for the crowd No taboos. Adverse reactions and risks Subcutaneous hemorrhage: subcutaneous hemorrhage due to less than 5 minutes of compression time or blood draw technique.