Anti-cyclic citrullinated polypeptide antibody (anti-CCP)

Anti-cyclic peptide containing citrulline (anti-CCP) is a multi-skin fragment of cyclic polypeptone, an antibody mainly composed of IgG. Anti-CCP antibodies are spontaneously secreted by B lymphocytes from RA patients, while B lymphocytes from other disease patients and normal population do not spontaneously secrete anti-CCP antibodies. Therefore, anti-CCP antibodies have a high specificity for RA. Its sensitivity is 76% and its specificity is 96%. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: 1 high specificity for the diagnosis of rheumatoid arthritis (90.4% ~ 98.0%); 2 contribute to the early diagnosis of rheumatoid arthritis; 3 may be related to the activity of rheumatoid arthritis; 4 most studies have suggested The positive rate is related to the degree of bone erosion, suggesting that the prognosis of RA is poor. Tips: Generally, it is required to take venous blood on an empty stomach, so it is forbidden to test after eating. Normal value The result of the test was negative. Clinical significance Abnormal results: 1 The specificity of diagnosis of rheumatoid arthritis is high (90.4%-98.0%); 2 contribute to the early diagnosis of rheumatoid arthritis; 3 may be related to the activity of rheumatoid arthritis; 4 Most studies have suggested that the positive rate is related to the degree of bone erosion, suggesting that the prognosis of RA is poor. People who need to be examined: Patients with rheumatoid arthritis generally require an examination. Positive results may be diseases: idiopathic arthralgia syndrome, finger sputum, synovitis considerations Contraindications before examination: Generally, venous blood is taken on an empty stomach, so it is contraindicated after eating. Requirements for inspection: Note that serum samples are not contaminated and sent to the test in time. Inspection process Detection of anti-CCP antibodies: ELISA was used. All subjects received 3 ml of venous blood, separated serum, and collected in a freezer at 20 ° C for examination. The anti-CCP antibody was quantitatively detected by enzyme-linked immunosorbent assay (ELISA). Not suitable for the crowd Inappropriate people: no special requirements. Adverse reactions and risks There are no related complications and hazards.