Cerebrospinal fluid protein characterization

Under normal circumstances, the protein content in the cerebrospinal fluid is much lower than that in the blood (the substances in the blood cannot enter the cerebrospinal fluid freely, and there seems to be a natural barrier). When the central nervous system develops a lesion, the diseased tissue can directly release the protein, and various proteins in the plasma easily break through the blood-brain barrier and enter the cerebrospinal fluid. Therefore, cerebrospinal fluid protein qualitative examination can reflect the disease state of the central nervous system, but no specificity. Basic Information Specialist classification: neurological examination classification: cerebrospinal fluid examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Found in the brain, spinal cord and meningeal inflammation, tumors, hemorrhage, etc., as well as brain softening, spinal cord tumors, degenerative brain diseases, radiculopathy, cerebrospinal fluid circulation obstruction and other diseases. Tips: Use aspirin, chlorpromazine, salicylate, penicillin, sulfonamides and other drugs, can interfere with protein qualitative test. Normal value Negative or weakly positive: (Pan's method). Negative: (Rojan Method). Clinical significance Positive is common in brain, spinal cord and meningeal inflammation, tumor, hemorrhage, etc., as well as brain softening, spinal cord tumor, degenerative brain disease, radiculopathy, cerebrospinal fluid circulation obstruction and other diseases. Positive results may be diseases: meningitis, spinal canal tumor considerations (1) Pan's method is highly sensitive; Luo Qiong method is mainly sensitive to globulin and has high specificity. Once the test is positive, the diagnostic value is large. (2) The use of aspirin, chlorpromazine, salicylate, penicillin, sulfonamides and other drugs can interfere with protein qualitative tests. Inspection process Pipette 2 ml of 5% carbolic acid solution in a small test tube, add 1 drop of cerebrospinal fluid, and see the presence of white cloud and turbidity on the black background with the sinking of cerebrospinal fluid. Not suitable for the crowd 1. If there is obvious papilledema or cerebral palsy, contraindications are contraindicated. 2. Patients who are in shock, exhaustion or endangered state and local skin inflammation, and lesions in the posterior cranial fossa are contraindicated. Adverse reactions and risks If the patient has symptoms such as breathing, pulse, or abnormal color during puncture, stop the operation immediately and deal with it accordingly.