Penicillosis
Introduction
Introduction to Penicillium Penicilliosis, also known as sputum plague, is rare and is caused by penicillium. Penicillium is often secondary to primary immune deficiency, AIDS, neutropenia, diabetes, long-term use of adrenocortical hormone, anti-tumor drugs, antibiotics, device artificial valves, etc., skin infections can cause similar gum-like ulcers , mostly in the groin, genitals and buttocks, pathological tissue has inflammation and fungal hyphae, spores, separation, branch hyphae. basic knowledge The proportion of illness: 0.001% Susceptible people: no specific population Mode of infection: non-infectious Complications: endocarditis, pericarditis
Cause
Cause of blue mold
Pathogenic bacteria infection (30%):
Penicillium marneffei is the only primary pathogen, which is a biphasic fungus. Other known pathogenic strains are Penicillium chrysogenum, Penicillium chrysogenum, Penicillium expansum, Penicillium decumbens and Penicillium chrysogenum ( Also known as common penicillium).
Prevention
Penicillosis prevention
Strengthen physical exercise, strengthen nutrition, and enhance the body's ability to resist disease. A reasonable diet can take more high-fiber and fresh vegetables and fruits, balanced nutrition, including essential nutrients such as protein, sugar, fat, vitamins, trace elements and dietary fiber, with a combination of vegetarian and vegetarian foods. The complementary role of nutrients in food is also helpful in preventing this disease.
Complication
Penicillin complications Complications, endocarditis, pericarditis
The disease can be complicated by endocarditis and pericarditis.
Symptom
Symptoms of blue mold disease Common symptoms Decay fungal infections dyspnea hemoptysis keratitis pericarditis bacteremia
1. Skin infection: It can cause similar gum-like ulcers, which occur in the groin, genitals and buttocks. In addition, there are reports of foot edema and hyperthyroidism.
2. Pulmonary infection: Non-specific, may have fever, weight loss, cough, cough, hemoptysis, difficulty breathing, X-ray may have focal pulmonary inflammation infiltration or cavity, or see "soap bubble" sign, also A lung abscess occurred.
3. Urinary tract infection: The clinical symptoms are similar to renal colic, which may cause fever, renal colic, hematuria, discharge of fungal masses, and the bacteria can be repeatedly cultured in the urine.
4. Endocarditis and pericarditis.
5. Fungal keratitis, fungal endophthalmitis.
6. Fungal bacteremia.
Examine
Examination of penicillosis
Fungal microscopy: visible branches of different color and size, separating hyphae.
Fungal culture: The growth rate is faster at room temperature, the colonies are velvety, flocculent, rope-like or bundle-shaped, the aerial hyphae are colorless or in various colors, and the conidial branch has a broom-like branch structure called Braided branches.
Pathological tissues include inflammation and fungal hyphae, spores, separation, and branched hyphae.
Diagnosis
Diagnosis and identification of blue mold
Diagnostic criteria
1. Clinical features
No specificity, according to patients with low immune function, long-term application of immunosuppressive agents, adrenal cortex hormones, and unexplained fever, brain, eye, urinary tract infection, poor antibiotic treatment, or heart valve transplantation, eye trauma, etc. Fungal infections should be considered.
2. Pathology
Pathological tissue has inflammation and fungal hyphae, spores, separation, branching hyphae.
3. Direct microscopic examination and culture of fungi
Multiple examinations are the same penicillium species, which can diagnose the disease.
Differential diagnosis
Penicillium disease needs to be differentiated from aspergillosis, and biopsy tissue is isolated and cultured, which is of great significance in differential diagnosis.
