Gardner syndrome
Introduction
Introduction to Gardner Syndrome Gardner syndrome, also known as Weiner-Gardner syndrome, familial multiple colon polyp-osteoma-soft tissue tumor syndrome, familial colon polyposis, is a chromosomal dominant disease, a multifaceted single gene which performed. In 1905, Gardner reported that colonic polyposis and familial osteoma, soft tissue tumors and colon cancer were more likely. Later, in 1958, Smith proposed a triad of colon polyps, soft tissue tumors and osteoma as Gardner syndrome. Unknown, colon polyps are adenomatous polyps, the cancer rate is 50%, and the bone tumors are benign. Both men and women can suffer and have a family history. basic knowledge The proportion of illness: 0.001% Susceptible people: no specific population Mode of infection: non-infectious Complications: gastrointestinal bleeding, intussusception, thrombosis
Cause
Cause of Gardner syndrome
Cause:
The etiology is unknown, and no genetic factors have been found. Some people think that it may be related to the lack of delayed type immune response in the small intestine. The pathological gastrointestinal tract has obvious mucosal inflammatory reaction, which is most obvious in the stomach and small intestine. The duodenum is most common in the polyps. The end is also more, the diameter of polyps can vary from a few millimeters to 3 centimeters, the difference is large, most scholars believe that the polyps are young-type hamartoma-like polyps, gastric mucosal lesions similar to Menetriey.
Prevention
Gardner syndrome prevention
This disease is a chromosomal dominant genetic disease with a family history, difficult to prevent, prenatal genetic disease screening, and prenatal and postnatal care are preventive measures for this disease.
Complication
Gardner syndrome complications Complications, gastrointestinal bleeding, intussusception, thrombosis
Common complications of this disease are gastrointestinal bleeding, infection, intussusception, cancer and thrombosis.
Symptom
Symptoms of Gardner Syndrome Common Symptoms Buried teeth, fatigue, weight loss, colon polyps, abdominal pain, abdominal distension, pigmentation, blood in the stool, dysfunction, mucus
Endoscopy and X-ray examination can determine digestive tract polyps and osteoma, and can be diagnosed by colon polyps, soft tissue tumors and osteoma.
1. Multiple polyps in the colon; the main symptoms are diarrhea, mucus or bloody stools, stomach, duodenum and other parts of the digestive tract other parts of the polyps have a higher rate of concomitant.
2. Soft tissue tumors: occur in the face, trunk or limbs, mostly sebaceous gland cysts, fibroid epidermis cysts, lipomas and so on.
3. Osteosarcoma: occurs in the flat bones of the jaw, humerus, sphenoid bone, etc., and the abnormal development of the teeth, such as multiple teeth, dental tumors, and buried teeth.
Examine
Gardner syndrome examination
X-ray barium digestive tract angiography revealed multiple polyps images, and digestive tract endoscopy revealed diffuse multiple polyps.
Diagnosis
Diagnosis and diagnosis of Gardner syndrome
It can be diagnosed based on clinical symptoms, signs and laboratory tests .
The disease should be associated with hereditary gastrointestinal polyposis with mucocutaneous pigmentation (Peutz-Jegher syndrome), hereditary colon polyp syndrome (Canada syndrome), Turcot syndrome, Gardner syndrome and other gastrointestinal polyposis Identification, these diseases are not accompanied by abnormal changes in ectoderm, which is helpful for identification.
