target-like hemosiderin deposition hemangioma
Introduction
Introduction to target hemosiderin-bearing hemangioma Initially it was a significant expansion of the superficial dermis and an irregular thin-walled vascular cavity. The ecchymotic ring is one of the typical symptoms of a target hemosiderin-bearing hemangioma. The disease is a subtype of a single hemangioma. Tumors that occur from vascular tissue are called hemangiomas, of which 80% are congenital. Hemangiomas are benign, slow-growing, and rarely malignant. basic knowledge The proportion of illness: 0.002% Susceptible people: no specific people Mode of infection: non-infectious Complications: hemangioma
Cause
Target-like hemosiderin-induced hemangiomatosis
Causes:
It may be caused by trauma and subsequent revascularization of the hemangioma with thrombus. In 1999, Carlson et al. studied 33 cases of this disease and considered it to be a subtype of single hemangioma.
Pathogenesis:
The study suggests that the disease is a subtype of a single hemangioma.
Important Pathological Changes of Target-like Hemoside Angiomas There are varying degrees of hemosiderin deposition in the thin-walled vascular sites of intradermal hyperplasia.
General pathological changes:
1, early: (1) shallow and thin vascular vascular extensive and dense irregular proliferation; (2) endothelial cells are epithelial, sometimes stratified, lumen disappeared; (3) intraluminal papillary, from a single layer The epithelioid-like endothelial cells are connected by spikes; (4) there are irregular stenotic vascular proliferation between the reticular dermal collagen bundles; (5) intradermal edema, red blood cell overflow, hemosiderin deposition and a small amount of lymphocyte infiltration.
2, late: (1) atrophic lumen; (2) extravascular extravascular spindle cells; (3) irregular, narrow thin-walled blood vessels traversing the collagen bundle of the dermis; (4) varying degrees of iron-containing blood Flavin deposition; (5) vascular endothelial cells were weakly positive for factor VIII-related antigen, and jingruin I was strongly positive.
Prevention
Target-like hemosiderin depositional hemangioma prevention
prevention
1. First, do not consume drugs and foods containing estrogen during pregnancy. Some scholars believe that the increase of estrogen content in human body is one of the causes of hemangioma.
2. Again, newborn babies can consider not breastfeeding first. This is also a consideration to avoid an increase in estrogen in the infant.
Complication
Target-like hemosiderin hemangioma complications Complications
There are usually no special complications.
Symptom
Target-like hemosiderin depositional hemangioma symptoms common symptoms ecchymosis papular pigmented lesions
The typical lesions are single-shot, ring-shaped lavender to purple papules with a diameter of 2 to 3 mm. The periphery is surrounded by grayish edges, and the periphery of the gray-white margin is a freckle ring, which makes the lesion appear as a target-like appearance. Finally, the late stage lesions are only slightly purple-brown papules, and most of the skin lesions occur in the trunk and limbs of young and middle-aged men.
Examine
Examination of target hemosiderin-bearing hemangiomas
Histopathology: early dermal hyperplasia and irregular thin-walled vascular hyperplasia, endothelial cells are flat or epithelial-like, papillary protrusions covered with monolayer epithelioid endothelial cells protrude into the lumen of the lumen, visible in the lumen Fibrinous thrombus, deep vascular endothelial cell lining in the reticular layer is not obvious, blood vessels become horny or irregular, in addition dermal edema, red blood cell extravasation, hemosiderin deposition, and mild lymphocytic infiltration, immune group The VIII-related antigen of vascular endothelial cells was weakly positive, and the hemagglutinin 1 of Jingjing was weakly positive.
Diagnosis
Diagnosis and identification of target hemosiderin-containing hemangioma
According to the clinical manifestations, combined with histopathological examination, immunohistochemical staining can be diagnosed.
