Abnormal platelet procoagulant activity
Introduction
Introduction to platelet procoagulant activity Platelet procoagulant activity is abnormal, also known as Scott syndrome, which is characterized by defects in platelet-promoting activity alone. The disease is autosomal recessive, and its etiology and pathogenesis have not yet been elucidated. basic knowledge Sickness ratio: 0.05% Susceptible people: no special people Mode of infection: non-infectious Complications: thrombosis
Cause
Abnormal cause of platelet procoagulant activity
Cause:
The cause is not clear.
Prevention
Abnormal prevention of platelet procoagulant activity
Pay attention to the usual life and find timely treatment in time.
Complication
Abnormal complications of platelet procoagulant activity Complications thrombosis
It may induce thrombosis.
Symptom
Symptoms of platelet procoagulant activity Symptoms Common symptoms Postpartum hemorrhage Menstrual volume More bleeding after extraction The hematoma formation
Patients with this disease are generally not susceptible to ecchymosis, but may have severe bleeding after tooth extraction, menorrhagia, postpartum hemorrhage and spontaneous pelvic hematoma.
Examine
Examination of abnormal platelet procoagulant activity
1. Serum prothrombin time: prolonged serum prothrombin time, which is the most constant abnormality, which reflects the decrease of prothrombin consumption during whole blood coagulation. It is a screening test for this disease, prothrombinase activity is reduced, and PF3 is effective. reduce.
2. The effectiveness of PF3 is induced by kaolin or the like after freezing or thawing, and the results are all reduced, reflecting the weakened ability of activated platelets to accelerate the blood coagulation process. It is considered that the determination of PF3 can reflect the distribution of platelet phospholipids, activated factor V and platelets. Phospholipids specifically bind to the process of further binding to factor Xa. Therefore, all of the defects of the phospholipids can cause a decrease in the measured PF3 activity. Therefore, in judging the results of the determination of the effectiveness of PF3, various factors should be noted.
3. Bleeding time is normal: It indicates that only the coagulation mechanism is abnormal, and there is no abnormality in initial hemostasis.
4. The number of platelets, morphology, adhesion, release and aggregation were normal.
The amount of Annexin V on the platelet surface was significantly reduced by flow cytometry.
Diagnosis
Diagnosis and differential diagnosis of platelet procoagulant activity
The diagnosis of this disease mainly depends on laboratory tests, the bleeding time is normal, prothrombin time is prolonged, prothrombin activity is decreased, and the effectiveness of PF3 is reduced to diagnose.
Due to the normal bleeding time of the disease, prolonged serum prothrombin time, and clinical manifestations of typical skin mucosal hemorrhage, it can be differentiated from other platelet function-deficient diseases. Recently, 4 cases of hereditary hemorrhagic disease have been reported. Platelet procoagulant activity is abnormal, platelet microvesicle production defects and bleeding time are slightly prolonged, and other indexes are normal. The difference from Scott syndrome is that prothrombinase activity is normal and PF3 is normal.
