verrucous acral keratosis
Introduction
Introduction to sacral keratosis Acrokeratosis verruciformis is rare and was first described by Hopf in 1930. At the time of birth or childhood, a small number of cases occur in adolescence, and women are about twice as many as men. It is autosomal dominant, often associated with follicular keratosis, or with follicular keratosis in the family. Therefore, it is believed that the two may be caused by the same keratinized genetic defect, and the damage is a flat or convex keratotic transitional solid papule with a diameter of 1 to a few millimeters, normal skin color or brownish red, similar to flat or scorpion epidermal dysplasia, number More, no fusion, skin damage can cause blisters, generally no symptoms. According to the flattened papules of the extremities, it persists and has a family history. The diagnosis is not difficult. There is no satisfactory therapy, you can try frozen, laser and other treatments. basic knowledge The proportion of illness: 0.0021% Susceptible people: no special people Mode of infection: non-infectious Complications: sepsis
Cause
Causes of sacral keratosis
(1) Causes of the disease
It is characterized by autosomal dominant inheritance, often associated with follicular keratosis, or with follicular keratosis in the family, so it is believed that both may be caused by the same keratinized genetic defect.
(two) pathogenesis
The pathogenesis is an autosomal dominant inheritance family, and there is currently no other relevant content description.
Prevention
Prolapse of sacral keratosis
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Complications of sacral keratosis Complications sepsis
Due to poor keratinization of the skin, destruction of skin integrity, and often accompanied by itchy skin, it may cause skin bacterial infection or fungal infection due to scratching, usually secondary to low body constitution, long-term use of immunosuppressants and nails, etc. Patients with fungal infections, such as concurrent bacterial infections, may have symptoms such as fever, swelling of the skin, ulceration, and purulent secretion. Severe cases can lead to sepsis.
Symptom
Symptoms of sacral keratosis common symptoms epidermal keratinized papules
Often at the time of birth or childhood, a small number of puberty, women are about twice as many as men, no ethnic or regional differences.
Damage is a flat or convex keratinized transitional solid papule, 1 to a few millimeters in diameter, normal skin tone or brownish red, similar to flattened or scorpion-like epidermal dysplasia, large number, no fusion, skin friction can cause blisters, generally No symptoms, lesions distributed in the extremities, mainly in the back of the hands and feet, can also be seen in the palmar, finger flexion, wrist, forearm, elbow, knee, palmar sac lesions appear as scattered translucent keratinized papules, may have Diffuse palmar skin thickening, the deck can be involved, the performance is thickening, whitening, damage gradually increased, and will not fade for the rest of life.
Examine
Examination of verrucous keratosis
Histopathology: obvious hyperkeratosis, thickening of the granule and acanthosis, mild papillary hyperplasia, no vacuolar degeneration and parakeratosis of epidermal cells.
Diagnosis
Diagnosis and differentiation of sacral limb keratosis
diagnosis
According to the flattened papules of the extremities, it persists and has a family history. The diagnosis is not difficult.
Differential diagnosis
1. Follicular keratosis: It is a scar-like scarring lesion, distributed in the area of sebum overflow, histopathological keratinization and lacunar and other characteristic changes.
2. Flat warts: flat papules, smooth surface, no hereditary, no involvement in palmar, pathological examination of epidermal cells with vacuolar degeneration.
3. Sickle epidermal cell dysplasia: The papules are rough, the lesions are widely distributed, the epidermal cells have extensive vacuolization, the flower basket is hyperkeratotic and the keratinization is poor.
4. Persistent lenticular keratosis: the germinal layer is flattened, and the shallow layer of the dermis has dense banded cell infiltration.
