Hyperinsulinemia
Introduction
Introduction to hyperinsulinemia Hypertension or obesity makes the biological effects of insulin impaired in hypertensive patients. At this time, the body's body is resistant to insulin, and in order to maintain a more normal blood sugar level, their body's self-regulating mechanism causes the islet cells to secrete several times or even ten times more insulin to lower blood sugar, which causes Hyperinsulinemia. Hyperinsulinemia is defined as an insulin content of 85 pmol/L in fasting blood. Hypertension or obesity makes the biological effects of insulin impaired in hypertensive patients. At this time, the human body is resistant to insulin, and in order to maintain a relatively normal blood sugar level, the body's self-regulating mechanism causes the islet cells to secrete several times or even ten times more insulin to lower blood sugar, which causes high Insulinemia. Physical activity can increase tissue sensitivity to insulin, reduce body weight, improve metabolism, reduce insulin resistance, relieve hyperinsulinemia, and reduce cardiovascular complications. basic knowledge The proportion of illness: 0.002% Susceptible people: no specific population Mode of infection: non-infectious Complications: coronary heart disease, hypertension, hyperlipidemia
Cause
Cause of hyperinsulinemia
Obesity (85%):
Hypertension or obesity makes the biological role of insulin weakened in patients with hypertension. At this time, the body's body is resistant to insulin, and in order to maintain a more normal blood sugar level, the body's self-regulation mechanism makes the islet -cell secretion more normal. More than a few times or even a dozen times more insulin to lower blood sugar, which causes hyperinsulinemia.
Prevention
Hyperinsulinemia prevention
Physical activity can increase tissue sensitivity to insulin, reduce body weight, improve metabolism, reduce insulin resistance, relieve hyperinsulinemia, and reduce cardiovascular complications.
Whether in China or in the West, people's diet is dominated by high calories and high fat. Excessive calorie intake exceeds consumption, causing fat accumulation in the body to cause obesity. Therefore, diet should be diversified to maintain nutritional balance and avoid overnutrition.
Complication
Hyperinsulinemia complications Complications, coronary heart disease, hypertension, hyperlipidemia
Insulinemia is the common pathogenesis of coronary heart disease, hypertension, hyperlipidemia, type 2 diabetes, obesity, and stroke.
Cardiovascular damage caused by hyperinsulinemia
The surrounding tissue is insensitive to insulin, which weakens the effect of insulin in the muscle and inhibits lipolysis of adipose tissue. Insulin resistance in adipose tissue leads to an increase in blood free fatty acid and triglyceride concentrations. High triglycerides and low density lipoproteins increase the risk of cardiovascular disease. Low-density lipoprotein can penetrate into the coronary arteries and other arterial intima to form atherosclerotic plaques that block blood vessels. Cardiac and cerebrovascular diseases, especially in women, occur early in diabetic patients with dyslipidemia. Female estrogen protects the heart and blood vessels, while diabetes eliminates the protective effects of estrogen. Hyperinsulinemia also damages vascular endothelial cells, causing platelet aggregation and allowing blood to aggregate easily. Insulin can also activate the sympathetic nervous system in patients with insulin resistance, causing vasospasm, increased resistance, and the development of essential hypertension. At the same time, the heart will be paralyzed, causing abnormal ventricular structure, decreased heart function and even failure.
Symptom
Hyperinsulinemia symptoms common symptoms fasting hypoglycemia hypoglycemia palpitations
Hyperinsulinemia is defined as fasting insulin 85 pmol/L.
Examine
Hyperinsulinemia check
1. Blood glucose measurement: When clinical symptoms occur, blood is taken to measure blood sugar. If blood sugar is lower than 40mg/dl, it can be used as an important diagnostic basis. However, blood is drawn at a later episode, and sometimes it can not reflect a serious hypoglycemia state due to fluid regulation and compensatory effects.
2. Qualitative diagnosis: starvation test, oral glucose tolerance test, insulin and proinsulin determination.
Diagnosis
Diagnosis and diagnosis of hyperinsulinemia
Patients with insulinoma must be identified with other diseases that cause fasting hypoglycemia. This disease is often misdiagnosed as epilepsy, cerebrovascular accident, rickets, schizophrenia, orthostatic hypotension, meningitis, encephalitis, brain tumor and diabetic acidosis, hyperosmolar coma, hepatic encephalopathy, hypopituitarism, Addison disease, hypothyroidism, autoimmune hypoglycemia, drug-induced hypoglycemia, non-insulinoma hypoglycemia, etc. The glucose tolerance curve of patients with various diseases can be significantly different, and the corresponding glucose tolerance test should be performed to observe the curve shape and provide reference for the differential diagnosis of hypoglycemia caused by various causes.
