saggy skin
Introduction
Introduction to skin sagging Dermatolysis, also known as skin relaxation (cutislaxa), or generalized elasticstolysis, is a skin sagging disease caused by congenital defects in skin elastic fibers and can invade systemic connective tissue. It involves the normal structure and function of cardiovascular, respiratory, urinary and other organs. Usually divided into two types: innate and acquired. basic knowledge The proportion of sickness: 0.4%-0.8% (the incidence rate in the middle-aged and elderly people over 50 years old is about 0.4%-0.8%) Susceptible people: no special people Mode of infection: non-infectious Complications: elastic fiber release and skin relaxation after inflammation
Cause
Cause of skin sagging
Genetic factors (35%):
Congenital type is autosomal recessive or partially dominant, and the acquired type has no genetic background and no family history, and is often based on secondary inflammation after skin inflammation.
Age factor (15%):
When the body ages, as the collagen disappears, the skin naturally appears aging and sagging, which is an inevitable trend of normal human development.
Improper maintenance (15%):
Some people who are not old enough are suffering from sagging and aging due to improper maintenance or occupational factors.
Pathogenesis
Congenital type, due to congenital copper ion metabolism abnormality affects the concentration of elastase inhibition, so that the elastic fiber congenital development defects and disease, obtained type, often due to skin inflammation secondary to this disease.
Prevention
Skin sagging prevention
Congenital type is autosomal recessive or partially dominant. Acquired people have no genetic background, no family history, and are often based on secondary inflammation following skin inflammation. Therefore, there is no way for clinical prevention to target genetic factors, which means that it can prevent dermatitis. For patients with dermatitis, active treatment should be done to avoid delaying the disease. Usually you should eat more animal skin rich in collagen, such as pig skin, fish skin and so on.
Complication
Skin sagging complications Complications , elastic fiber release and skin relaxation after inflammation
Congenital type may have corneal annular hemangioma, tongue surface cracking, uvula sag, tooth loose, swollen pharyngeal mucosa, vocal cord relaxation, hoarseness, sparse hair and genital dysplasia.
Symptom
Symptoms of skin sagging Common symptoms ptosis, valgus, eversion, edema, skin involvement, nasolabial fold, deep eczema
Congenital type
Skin symptoms were found shortly after birth. Skin edema was first seen. Later, the skin was slack and sagging was creased. The neck, face and eyelid wrinkles were the most prominent, showing an early appearance. The ptosis can obstruct the line of sight and squat. Drooping, valgus, ventral wall, neck and skin relaxation, other organs elastic fiber damage, tissue relaxation, often can occur oblique, gastrointestinal diverticulum, mucosal prolapse and cardiovascular dilatation or aneurysm, etc. There may be corneal annular hemangioma, tongue cracking, uvula sulcus extension, loose teeth, swollen pharyngeal mucosa, vocal cord relaxation, hoarseness, sparse hair and genital dysplasia, common skin involvement sites, Eyelids, ears, neck-based, followed by wrist, knee, ankle, abdominal skin folds.
2. Acquired
Usually adult disease, some may have skin inflammation, after the elastic tissue release and relaxation, such as eczema, polymorphic erythema, urticaria, angioedema may appear skin relaxation symptoms, but no congenital developmental disorders.
Examine
Skin sagging check
Histopathology: The skin elastic fiber is obviously reduced or absent, the deep elastic fiber is denatured, the thickness is uneven or dissolved, the outline is unclear, the fiber breaks and the granular degeneration can be seen by electron microscopy, and the elastic fiber changes seen by other affected organs are similar to the skin tissue morphology. .
Diagnosis
Skin sagging diagnosis
diagnosis
According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.
Differential diagnosis
Excessive skin elasticity
The skin looks normal, does not sag, no wrinkles, strong elasticity rather than slack and weakness, increased fragility, and easy to become scars.
2. Elastic fiber pseudo-xanthoma
Skin relaxation is common on the neck side, wrinkles are yellow, facial surface is rarely affected, and histopathology can be identified.
3. Neurofibroma
The sagging of the skin is limited by softness and empty sac, with asymmetrical distribution, accompanied by special coffee spots.
