Hydrolysine

Hydroxylysine is another product of collagen degradation. It mainly has two glycoside forms: GHYL (glycoside hydroxylysine) and Glc.GHYL. Hydroxylysine and its glycoside products are not as high in urine as hydroxyproline, but because its content is fixed, it is not affected by food sources, and it has high tissue specificity, so it has more Better representation. One third of hydroxylysine in bone and skin is glycosylated, Glc. GHYL / GHYL is 1.6: 1 in skin and 1: 7 in bone. Monoclonal antibodies against GHYL have been developed for clinical testing and are a more sensitive indicator of bone resorption.