Anti-centromere antibody

Centromere, also known as centromere, is a narrow segment structure in a chromosome. Before cell division, each chromosome is composed of two chromatids with the same gene. They are combined at the centromere, and in mitosis, they are connected to the puller filaments of the spindle poles to stain the two. The monomers are pulled in the direction of their corresponding centrioles. Centromere antigens are composed of three centromere proteins (Cen P), namely Cen PA (17kD), Cen PB (80kD), and Cen PC (140kD). Cen PA is a centromere-specific core histone that may have a direct role in the packaging and function of chromosome centromeres. Cen PB is the main component of centromere antigen. It is a DNA-binding protein that is rich in & alpha; satellite DNA (also called satellite DNA) and is concentrated in the dividing chromosome and the nucleus of the interphase. Cen PC is a large molecular weight protein in centromere antigens, and its role is unknown. In dividing cells, the centromeric antigen is separated from the concentrated chromosome, and during the cell division period, the antigen is present on the concentrated chromosome, and on a single stretched chromosome, the antigen is located in the main chromosome region. Anti-centromere antibodies are a limited type in systemic sclerosis, also known as CREST [calcinosls calcium deposits, Raynaud & rsquo; s phenomenon, Renoir phenomenon, esophageal dysmotility esophageal dyskinesia, sclerodactyly scleroderma. There are many reports of telangiectasis capillary telangiectasia syndrome antibodies, which are mutually exclusive with anti-Scl-70 antibodies. It is extremely rare that both are positive.