Anti-myosin antibody

Cardiac myosin (CM), also known as myosin, is the main component of thick myofilament and the most common structural protein in cardiomyocytes. CM is composed of two subunits, one heavy chain (MHC) and two light chains (MLC). The light chain is divided into light chain I (MLC-I) and light chain II (MLC-II). CM is similar in function to skeletal muscle, but differs in amino acid organization and structure. Therefore, the antigenic determinants formed are also different from skeletal muscle and smooth muscle. Therefore, a cardiac-specific antigen can be provided, and a cardiac-specific anticardiac anti-myosin antibody (AcMA) can be generated. Myosin causes immune myocarditis and dilated cardiomyopathy patients to generate immune responses and produce specific antibodies. At present, there are two possible mechanisms: ① virus infection or other causes of myocardial tissue necrosis leading to myosin release and exposure, Trigger an individual's autoimmunity. ② Virus molecules have similar epitopes to myosin.