Cerebrospinal fluid endothelin

Cerebrospinal fluid endothelin (ET) is a class of active peptides that are widely distributed in various tissues such as vascular smooth muscle, kidney, heart, spinal matter, liver and spleen. It has been shown that endothelin-1 is produced only by endothelial cells, endothelin-2 may be produced in the kidney, and endothelin-3 may be produced mainly in neural tissues. Endothelin biosynthesis consists of proendothelin (38 to 39 amino acids) produced by protoplastin (203 amino acids) in cells and hydrolyzed by endopeptidases, and then endothelin (21) Amino acid residues). Endothelin in the systemic circulation is not easy to penetrate the blood-brain barrier. Experiments have shown that endothelin is mainly distributed in the hypothalamus, thalamus, lateral ventricle, pale globules, caudate nucleus, brain stem including pontine. Physiological function is the strongest known vasoconstrictor substance, which has a positive inotropic effect on the myocardium. It acts not only as a main transmitter but also a secondary transmitter in the brain and spinal cord. The ET produced by the central nervous system is mainly used as a neuromodulating peptide. Involved in paracrine and autocrine forms in blood pressure, behavioral regulation, and transmission of neural information.