Urinary prostaglandin

PG is a family of biologically active substances belonging to unsaturated fatty acids. It has a variety of physiological functions and can also be used as an information regulating molecule. It can affect the body's development, growth, and regulation by regulating the levels of genetic information (RNA, DNA), neurotransmitters and hormones Reproduction and a range of neuroendocrine effects. PG is widely present in many tissues and body fluids, with the highest concentration in semen. At present, more than 20 species have been found. According to their different five-carbon ring structures, they are divided into A, B, C, D, E, F, G, and H types. PGE, PGF, PGA, and PGB types are the most important. According to the number of double bonds contained in the side chain, it is further divided into three compounds, such as type E, which can be divided into PGE1, PGE2, and PGE3. PGE1, PGE2, F1a, F2a, etc. are widely distributed in the brain, spinal cord, peripheral nerves, and CSF, with E2α being the most abundant. PGE2a is a cerebral vasoconstrictor. When cerebral vasospasm occurs, the concentration of TGF2a in CSF can be seen to increase.