Anti-streptococcal wall polysaccharide antibody

Group A hemolytic streptococcal cell wall specific polysaccharides and human heart valve glycoproteins have cross-antigenicity. When group A hemolytic streptococcal infection in humans, it can stimulate the body to produce anti-streptococcal polysaccharide antibodies (antibody to streptococcal polysaccharide, (ASP). This antibody can cause damage to the heart valve and cause rheumatic heart valve disease. It has been determined that the most biologically active part of the antigen is 38KD, and the values ​​of its IgG and IgM parts can be detected by ELISA, which is easier to popularize in clinic. Because the level of this antibody can better reflect the damage of heart valve, this antibody can not only support the existence of previous streptococcal infection and the current acute rheumatic fever autoimmune response, but also can predict the prognosis of rheumatic fever, so it is clinically Have greater reference value.