Aneutrophil

(1) Uneven cell size: Some cells have enlarged somatosomes, and some become smaller. Seen in prolonged pyogenic inflammation or chronic infection. It may be caused by the irregular division and proliferation of naive neutrophils in the bone marrow under the action of factors such as endotoxin. (2) Toxic granules: Dark purple or blue-black granules appearing in the cytoplasm of neutrophils that are coarse and uneven in size are called poisoning granules. It is spindle-shaped or oval-shaped under electron microscope, with higher density and higher alkaline phosphatase activity. Such particles are more common in severe purulent infections and large-scale burns. In severe purulent infections, neutrophil alkaline phosphatase (NAP) staining often shows a significant increase in enzyme activity. (3) vacuoles: vacuoles of different sizes and numbers appear in the cytoplasm or in the nucleus of granulocytes, which are generally considered to be after cell damage. Caused by steatosis in the cytoplasm. Common in severe infections. (4) Nuclear degeneration: There may be nuclear condensation, nuclear dissolution, and nuclear fragmentation. When the nucleus was condensed, the chromatin aggregated into a dark purple and massive clot. When the nucleus is lysed. The nucleus swelled, often accompanied by fragmented nuclear membrane, loose or fuzzy nuclear chromatin structure, and pale staining.