Plasminogen activator

Tissue plasminogen and cargo is a single-chain glycoprotein, which is mainly synthesized, secreted by vascular endothelial cells, and continuously released into the blood. It is widely present in various tissues of the body, and the liver is inactivated by tissue plasminogen activator. Main place. It has a high affinity for fibrin, and then turns tyrosine plasminogen into plasmin, which degrades fibrin (pro) and some coagulation factors, and is a key substance of the fibrinolytic system.