Bone sclerosis

Bone sclerosis is an increase in bone density accompanied by a slight change in shape. Delayed bone sclerosis occurs in childhood, adolescence or early adulthood. Albers-Schonberg disease strictly refers to autosomal dominant hereditary, delayed, delayed, benign Type of bone sclerosis, the geographical and ethnic distribution of the disease is relatively widespread. The affected patient may be asymptomatic, or may be diagnosed by accidental discovery during X-ray examination for other reasons. Face, physique, intelligence and life expectancy are normal Health is generally unaffected. Occasionally, facial paralysis or deafness is caused by cranial nerves being compressed by overgrown bones. Mild anemia is a rare complication. X-ray examinations of bones are usually normal at birth, as children progress, Bone sclerosis gradually becomes apparent. Bone involvement is extensive but spotted, osteoporosis at the extremities of the limbs, dense cranial bones, paranasal sinus occlusion, spinal vertebral endplate sclerosis, "rugby jersey" -like shape. Some patients need blood transfusion Or splenectomy for anemia. Precocious osteosclerosis (autosomal recessive, precocious, malignant, congenital osteosclerosis that occurs in infants) is an uncommon Potentially fatal disease. Excessive bone growth results in bone marrow dysfunction and manifests various symptoms, including poor growth, spontaneous ecchymosis, abnormal bleeding, and anemia. Progressive hepatosplenomegaly occurs in the later stages of the disease Large, paralyzed ophthalmic, oculomotor and facial nerves. Anemia, uncontrollable infection, or bleeding often occur during the first year of life. Increased bone density throughout the body is a significant radiological feature. Penetration of long bones The photographs revealed growth barriers in the epiphyseal region and longitudinal stripes on the backbone. As the disease progressed, the two ends of the long bone, especially the proximal humerus and the distal femur, formed a "flask". In the vertebrae, pelvis and tubular bone Intraosseous osteogenesis, thickened skull, and spine-like "rugby shirt". Bone marrow transplantation has produced excellent initial results for a small number of infants, but the long-term results are unknown. Osteosclerosis with renal tubular acidosis is a An autosomal recessive hereditary disease, resulting in weakness, short stature, and poor growth. Dense radiographic density of bones, manifesting renal tubular acidosis, and loss of red blood cell carbonic anhydrase activity. Dense bone dysplasia is a type of often stain Recessive hereditary diseases, with obvious short stature in early childhood; adults not exceeding 150 cm tall. Other manifestations include large skulls, short and wide hands and feet, malnourished nails, blue sclera, usually in infancy It can be recognized. The affected patients are very similar, with small faces, retracted mandibles, and dental caries and misaligned jaws. The skull is bulging, the anterior condyle is not closed. The short finger (toe) bone is short and the fingernails are poorly developed. Sexual fractures are a complication of dense bone dysplasia.