Increased alkaline phosphatase

Alkaline phosphatase (ALP or AKP) is an enzyme widely distributed in the human liver, bones, intestines, kidneys, and placenta, and is excreted by the liver to the gallbladder. This enzyme catalyzes the removal of 5 'phosphate groups from nucleic acid molecules, thereby converting the 5'-P end of a DNA or RNA fragment into a 5'-OH end. But it is not a single enzyme, but a group of isoenzymes. At present, six isozymes of AKP1, AKP2, AKP3, AKP4, AKP5 and AKP6 have been found. The first, second, and sixth are all from the liver, the third are from bone cells, the fourth are from the placenta and cancer cells, and the fifth are from the small intestinal villi epithelium and fibroblasts. Alkaline phosphatase is mainly used for the inspection of obstructive jaundice, primary liver cancer, secondary liver cancer, and cholestatic hepatitis. When suffering from these diseases, liver cells overproduce ALP, enter the blood through the lymphatic tract and sinus, and at the same time, due to the bile excretion disorder in the liver, the serum alkaline phosphatase is significantly increased.