Paraquat poisoning

Paraquat, called paraquet lung (1.1 dimethyl-4. 4 dichlorodipyridine 1.1-dimethyl-4. 4-dipyridium dichloride) is a strong weed killer Tinctures have a strong toxic effect on humans and animals. Most are poisoned by oral administration by suicide or by suicide, but can also be fatal by absorption through the skin. The clinical manifestations of paraquat poisoning are: intake of herbicides can cause burning sensation in the tongue, mouth and throat, esophagitis and gastritis, vomiting and abdominal pain. The excretion of the drug from the kidney can damage the renal tubules, produce proteinuria, hematuria, blood urea nitrogen, elevated creatinine and other manifestations of renal impairment. The respiratory system is mainly manifested by progressive dyspnea and cyanosis, which eventually leads to respiratory failure and death. Chest X-ray manifestations: initially scattered fine speckled shadows, more lung fields below. Rapid progress, the fusion of the lesions showed a severe pulmonary edema-like morphology. Pulmonary function is mainly manifested by carbon monoxide diffusion disorder, moderate airway obstruction, and / or restricted ventilation abnormalities. Heart, liver and adrenal poisoning can cause corresponding symptoms and signs. Paraquat is a bipyridine compound. Such herbicides can damage most internal organs, especially the lungs, heart, liver, and kidneys after swallowing, and can cause death within a few hours. Most of the poisoning caused by paraquat is caused by intentional suicide. Although the metabolite bipyridine is absorbed relatively slowly in the intestine, after oral administration of paraquat which exceeds the toxic dose, bipyridine will be widely distributed in the body within 6 to 18 hours, and the amount will be in various important organs and tissues. Can reach lethal. At this time, even if immediate measures are taken to remove bipyridine from the blood, it is not easy to reduce the load of each organ in the body.