Wider tooth pitch

Widening of the interdental space is one of the symptoms of mannosidosis type II. Mannosidosis type 2 develops more than 2 years of age, with normal physical and psychomotor development. After 2 years of age, progressive brain retardation begins, frequent respiratory infections, ugly face, thick eyebrows, wide incisors, and convex jaws. , Low front hairline, mild bilateral deafness (mostly sensory). Some patients may have reduced whole blood.