Cryoglobulin precipitates or jelly

Primary cryoglobulinemia is more common in young and middle-aged people, with women slightly more than men. When the patient's body temperature decreases due to cold, the cryoglobulin in the blood vessels of the extremities will precipitate or gel, blocking the capillaries, and causing ischemic necrosis and vasospasm of the blood vessel wall, purpura and cold nettle appear on the skin. Measles is the most common, and some patients may have Raynaud's phenomenon.