Only soft tissue in the thumb without bones

Skeletal deformities can affect both upper limbs and are heavier on the left. Variations or absences of forearm, wrist, and radial bones are the most common. Radial wrist bones can cause the base of the first metacarpal to approach the midline due to delayed ossification, juxtaposed with other metacarpals, and the fish can disappear, because the thumb and other limbs are at the same level. Therefore, the palm function is lost. The thumb variation is a characteristic change of this symptom. It is usually a subluxation, three fingers, three thumbs, and the last bend to the ulnar side, bifurcation, short or absent, or the thumb only has soft tissues without bones. Hand-heart malformation syndrome is cardiovascular-limb syndrome, also known as Holt-Oram syndrome, atrial-finger syndrome, atrio-digital syndrome, cardiovascular syndrome of the upper extremities, Upper limb defects, atrial dysplasia, atrio-digital dysplasia syndrome, etc. The disease is an autosomal dominant hereditary disease, with cardiovascular malformations and skeletal malformations as the main clinical manifestations.