Cortical hypofunction

When most of the adrenal glands on both sides are destroyed, there are various manifestations of corticosteroid deficiency, which is called adrenal insufficiency. Can be divided into primary and secondary. Primary chronic adrenal insufficiency, also known as Addison's disease, is relatively rare; secondary hypothalamic-pituitary insufficiency can be seen, due to insufficient secretion of CRF or ACTH, resulting in atrophy of the adrenal cortex.