Fatal familial insomnia

This disease is a subacute familial TSE. It is clinically characterized by ineffective insomnia, autonomic dysfunction, and motor signs. Histopathology is characterized by selective atrophy of the anterior ventral and medial dorsal nucleus of the thalamus. Earlier, the disease was confused with familial CJD. In 1986, the first case of the disease was first reported and described in detail by Lugaresi et al. Of the Faculty of Medicine, University of Bologna, Italy, and was named fatal familial insomnia. Since then, a new member has been added to human prion disease.