Ketonuria

Severely hungry or untreated diabetic patients have low blood glucose levels leading to increased gluconeogenesis, accelerated oxidation of fatty acids to produce a large amount of acetyl-CoA, and gluconeogenesis depletes oxaloacetate, which is where acetyl-CoA enters the citric acid cycle It is necessary that acetyl-CoA turns to the direction of ketone body. Eventually a large number of ketone bodies appear in the blood and urine.