Anti-sperm antibody-positive infertility

Antisperm antibody (AsAb) is a complex pathological product that can be affected by both men and women, and the exact cause is not fully understood. Men's sperm and seminal plasma are specific antigens for women. After contact with blood, both men and women can cause an immune response, produce corresponding antibodies, hinder sperm from binding to eggs, and cause infertility. The above-mentioned cases belong to sperm immune infertility. The female reproductive tract, especially the macrophages in the uterus, recognizes sperm as a "foreign body" when it is AsAb-positive and swallows it. Under normal circumstances, there is no AsAb in women's blood, but in the above-mentioned special cases, the female body "self-defenses" the sperm and semen antigen, "the family does not know the family", causing the immune system to produce antibodies. In men, it is "self-defense" that causes its own immune system to produce antibodies, resulting in "cannibalism" and making it difficult for sperm to survive.