Neonatal persistent cholestatic jaundice

Infant cholestasis (cholestasis) refers to the persistent reduction of bile excretion in infants caused by liver cell damage and / or intrahepatic and external bile duct obstruction. The main clinical manifestations are hyperconjugated bilirubinemia [ie, blood direct bilirubin 25.5micro; mol / L (1.5mg / dl), or the ratio of straight and total bile of 20%], hepatosplenomegaly, and abnormal liver function And fat malabsorption. Some people call this disease infantile hepatitis syndrome. Since the included cases do not all have the pathological changes of hepatitis, this name deserves further discussion. Here mainly discusses the onset of cholestasis within 3 months after birth.