Uremic coma

Uremic coma refers to severe renal dysfunction, metabolic waste cannot be excreted, so a large amount of nitrogen-containing metabolites and other toxic substances are accumulated in the body, water and electrolyte metabolism and acid-base balance are disturbed, and the relative stability of the internal environment of the body is destroyed. The combined symptoms of self-poisoning and the resulting disease are called uremia. Often manifested as azotemia, markedly elevated blood urea nitrogen and creatinine, accompanied by symptoms of the gastrointestinal, neuromuscular, and cardiovascular systems, such as nausea, vomiting, diarrhea, headache, weakness, apathy, insomnia, convulsions, lethargy Even coma and other symptoms. There are many causes of uremia. Diseases of the kidney itself, such as chronic glomerulonephritis, pyelonephritis, etc .; kidney diseases caused by systemic diseases, such as hypertensive nephrosclerosis, systemic lupus erythematosus, etc .; and urinary tract obstruction, which cause severe damage to the renal parenchyma, a large number of nephrons Destruction can cause uremia when severe renal dysfunction occurs.