Renal damage in hyperthyroidism

Hyperthyroidism (hyperthyroidism for short) refers to a clinical syndrome caused by an increase in thyroid hormone levels in the blood circulation caused by a variety of reasons. Clinically, it is characterized by hypermetabolism, goiter, exophthalmia, and nervous and cardiovascular system dysfunction. Pathologically, the thyroid can be diffuse, nodular, or mixed. Increased thyroid hormone levels in the blood circulation can cause a series of changes in the kidneys. There are mainly renal vasodilation, renal plasma flow, glomerular filtration rate, renal tubular reabsorption rate, and excretory capacity all increased. At the same time, due to the increase in renal medullary blood flow, the decrease in the solute concentration in the medullary medicament reduces the osmotic pressure, resulting in impaired renal tubular condensing function. Due to increased bone breakdown during hyperthyroidism, kidney disease and even renal insufficiency may occur due to moderate hypercalcemia. A small number of patients may be complicated by renal tubular acidosis.