Hypertrophic obstructive cardiomyopathy

Hypertrophic obstructive cardiomyopathy was once called subaortic muscular obstruction. Davies reported in 1952 that five of the nine siblings had the disease, and three of them had sudden death. Teare described the ventricular septal hypertrophy in 1958, which was much thicker than the left ventricular free wall. And the cardiomyocytes are thick and short, the arrangement is disordered, and the lateral connections between cells are abundant. This is called asymmetric ventricular septal hypertrophy. It is considered a type of primary cardiomyopathy after 1960, accounting for about 20% of various cardiomyopathy, so it is called idiopathic obstructive cardiomyopathy, idiopathic hypertrophic aortic stenosis or hypertrophy Obstructive cardiomyopathy. About 30% of the cases have a family history and may have genetic factors. The onset time can range from infants to over 60 years old, but the most common is between 10 and 30 years old, suggesting that it may be congenital malformation or acquired. From 1960 Goodwin, Kelly, Morrow, Brockenbrough, Braunwald, Wigle, etc. have carried out surgical treatment of this disease.