Fibrosis syndrome

Fibrosis syndrome, also known as multifocal sclerosis, is a non-infectious granulomatous disease. It is characterized by progressive fibrous tissue hyperplasia and sclerosis of multiple organ systems. The most common is hydronephrosis caused by fibrosis around the ureter, followed by fibroproliferative mediastinitis and fibrosclerotic cholangitis, which can also affect other organ systems. This syndrome can occur in several organ systems, or it can be manifested as one organ involvement.