gout

Gout is caused by an increase in purine biosynthesis, an increase in uric acid production, or an increase in uric acid in the blood due to poor excretion of uric acid, and the deposition of urate crystals in the joint synovium, bursa, cartilage and other tissue Of recurrent inflammatory diseases. The first attack often involves a single joint, and the first metatarsophalangeal joint is often involved. Showed as joint redness, burning, tenderness, and limited function. Typical attacks are: pain onset reaches a peak within 24 hours; remission occurs within 14 days; after the relief of acute arthritis, there are generally no obvious sequelae. The disease is characterized by birefringent sodium urate monohydrate crystals found in synovial fluid and gout stones. Its clinical features are: characteristic acute arthritis, gout stones, interstitial nephritis caused by hyperuricemia and urate crystals and deposition. In severe cases, joint deformities and dysfunction are seen, often accompanied by uric acid urinary stones. More common in obese middle-aged men and postmenopausal women. With economic development and lifestyle changes, its prevalence has gradually increased.