Postmenopausal osteoporosis

Postmenopausal osteoporosis (POP) is a common disease related to aging. It mainly occurs in postmenopausal women. Due to estrogen deficiency, bone mass decreases and bone tissue structure changes, which increases bone fragility and is prone to fracture. And the pain, bone deformation, comorbidities, and death caused by fractures seriously affect the physical health and quality of life of the elderly, and even shorten lifespan, increasing the financial and human burden of the country and family. Menopause-related osteoporosis is an important health issue that cannot be ignored. In 1993, the WHO defined osteoporosis as a systemic decrease in bone mass, accompanied by changes in the microstructure of bones, leading to increased bone fragility and increased risk of fractures. The 2001 consensus meeting of the National Institutes of Health suggested that osteoporosis is a bone disease characterized by impaired bone strength, leading to an increased risk of fractures. Bone strength reflects bone density and bone mass. The pathological characteristics of osteoporosis are a proportional reduction in bone mineral content and bone matrix components, thinning of the cortex, reduction and thinning of trabeculae, and trabecular fracture in postmenopausal osteoporosis.