Adrenaline poisoning

Adrenalin and noradrenalin are commonly used first-aid drugs, and overdose can cause poisoning. A small number of patients are highly sensitive to adrenaline, and adverse effects can occur even at therapeutic doses. Children with previous hyperthyroidism and cardiovascular disease are also more sensitive to adrenaline and are prone to poisoning. A small dose of epinephrine can excite the central nervous system and can be used to treat anaphylactic shock. A large dose of epinephrine can excite the central nerve while causing convulsions and inhibiting the respiratory center. A large amount of adrenaline can still cause acute pulmonary edema.