Glioblastoma

Glioblastoma is the most malignant glioma in astrocytic tumors, which belongs to WHO class IV. The tumor is located under the cortex and grows invasively. It often invades several brain lobes and deep structures. It can also spread to the contralateral cerebral hemisphere through the corpus callosum. Occurrence sites are most common in the frontal lobe, others in the temporal lobe / parietal lobe, and a few can be found in the occipital lobe / thalamus and basal ganglia. Glioblastoma can be primary in the brain parenchyma or secondary. Most secondary glioblastomas are further malignant from anaplastic astrocytoma, and a small part can evolve from mixed gliomas, oligodendrogliomas, or ependymal tumors.