Chronic granulomatosis

Chronic granulomatous disease (CGD) is a hereditary granulocyte bactericidal dysfunction disease characterized by extensive granulomatous damage to the skin, lungs and lymph nodes. Most patients are male. X-linked recessive inheritance; a few are autosomal recessive. Both sexes can develop. The main drawback is that the host phagocyte system produces insufficient hydrogen peroxide, which cannot kill catalase-positive bacteria, causing widespread infection. Granuloma is a response to pyogenic infections, often infiltrated and surrounded by pigmented lipid tissue cells. Clinical manifestations are characterized by recurrent severe infections and the formation of pigmented granulomas at the sites of repeated infections.