Multifocal motor neuropathy

Multifocal motor neuropathy (MMN) is also called multifocal motor neuropathy. It is a rare demyelinating peripheral nerve disease that has been recognized in recent years. From 1985 to 1986, Parry et al. And Roth et al. Reported four cases of pure motor neuropathy at the same time. The clinical manifestations were progressive asymmetric limb weakness, mainly distal involvement, and the electrophysiological feature was the presence on the motor nerve. Continuous multifocal conduction block (CB), with no or only minimal involvement of sensory nerves. In 1988, Pestronk et al. Reported for the first time that serum levels of anti-ganglioside GM1 antibodies were elevated in patients with the disease and responded to immunotherapy. Since then, most scholars believe that this disease is different from chronic inflammatory demyelinating polyneuropathy (CIDP) and motor neuron disease, but a separate disease called multifocal motor neuropathy. As early as 1982, Lewis et al. Reported 5 cases of motor sensory neuropathy with similar clinical and electrophysiological characteristics, and 2 cases had improved symptoms after treatment with corticosteroids. At present, most scholars believe that these cases are variants of CIDP. It differs from MMN in that the former has sensory nerve involvement and is effective for corticosteroid treatment. So far, more than 300 cases of MMN have been reported worldwide.