Progressive supranuclear palsy

Progressive supranuclear palsy (PSP) is a progressive neurological degeneration disease with pontine and midbrain neuron degeneration and neurofibrillary tangles (NFT) as main pathological changes. Because of this disease, the head has hyperextension dystonia posture and eye movement disorders, also known as oculocervical dystonia. The disease was first reported by Posey (1904). In 1963, RichARD Son and Steele and Olszewski considered progressive nuclear paralysis as an independent disease of clinical pathology. In 1972, Steele described the clinicopathological characteristics of the disease in detail, also known as Steele-Richardson-Olszewski syndrome. At that time, 73 cases of PSP were reported in the medical literature, of which 22 were autopsies, which were found in almost every major neurological disease center. There are several cases, so PSP is not uncommon. The main clinical features of this disease are posture instability, dyskinesia, vertical supranuclear palsy, pseudobulbar palsy, and mild dementia.