Glycogen storage disease

Glycogen storage disease (glycogen storage disease) is due to the lack of certain enzymes in the glycogen metabolism of liver, muscle and brain tissues, which prevents glycogen from normally breaking down or synthesizing. Group recessive hereditary glycogen metabolism disorders, also known as glycogen diseases, glycogenoses. The disease was first discovered by several doctors in the Netherlands in 1928 and 1929. Most of them were deficient in glycogenolytic enzymes, and glycogen was degraded in tissues and deposited excessively; very few were due to the lack of glycogen synthase, which appeared as tissues. Glycogen is stored too little. The disease affects multiple organ tissues, mainly the liver, kidneys, heart, and muscles, and most of them are hypoglycemic. The disease is divided into liver-hypoglycemia glycogen storage disease and muscle-energy disorder glycogen storage disease.