Melanin plaque-gastrointestinal polyposis syndrome

The melanin spot-gastrointestinal polyposis syndrome (Peutz-Jegher Syndrome) is an autosomal dominant hereditary disease caused by a mutation in a gene called STK11 or LKB1 on the 19p chromosome. It is characterized by the occurrence of melanin spots on the ventral sides of the fingers and toes on the lips and around it, as well as multiple polyps of the digestive tract. Half of the patient's children may have the disease, and both men and women can develop the disease, and the incidence rate in the population is 1 / 160,000-28,000. There are many patients with the same family, with a family history of 40%.