Iris corneal endothelial syndrome

Iridocorneal endothelial syndrome (ICE syndrome) usually develops in one eye, and is more common in 20 to 50 years old. There are more women than men. They are characterized by abnormal corneal endothelium, progressive atrophy of the iris matrix, extensive peripheral anterior iris adhesion, Angle closure and a group of diseases of secondary glaucoma. The disease name was proposed by Eagle and Yanoff, and it represents a group of diseases of the anterior segment of the eye with primary corneal endothelial abnormalities. Corneal endothelial lesions are directly responsible for corneal edema, progressive closure of iris corneal adhesions, significant iris destruction, and secondary glaucoma to varying degrees. In this series of ICE syndrome, there are three clinical types of progressive iris atrophy, Chandlel syndrome and Cogan-Reese syndrome, which are mainly distinguished based on iris changes.