Salicylic acidosis

Salicylates poisoning refers to salicylic acid reaction caused by salicylic acid reaction caused by excessive or long-term use of salicylates. Salicylates commonly used in clinical practice are aspirin (acetic acid, acetylsalicylic acid), compound aspirin, sodium salicylate, sodium salicylate mixture, methyl salicylate (winter green oil), and others Contains salicylic acid tinctures, ointments, etc. Accidents of overdose are more likely to occur during infancy. External salicylic acid ointment or powder can be absorbed and poisoned through the skin on large areas of skin damage. Patients with dehydration, liver and kidney dysfunction, and hypothrombinemia are more prone to severe toxic reactions. Salicylate can pass through the placental barrier. Pregnant women take too much and often cause fetal or neonatal poisoning. Ingestion of aspirin or sodium salicylate in children 2 to 4 times the amount of treatment can cause symptoms of poisoning. The minimum lethal dose of aspirin is about 0.3 to 0.4 g / kg. The minimum lethal dose of sodium salicylate is about 0.15g / kg, and the lethal dose of pediatric wintergreen oil is about 4ml.