Myasthenia gravis

Myasthenia gravis (MG), physiologically considered to be a chronic disease with neurotransmitter transmission dysfunction; immunological studies have antibodies against acetylcholine receptors in patients' blood, making effective体 REDUCTION. Therefore, myasthenia gravis is an autoimmune disease with dysfunction in the transmission of neuro-muscular junctions (synapses). Acetylcholine receptors (AchR) on the post-synaptic membrane at the nerve-muscle junction of the striated muscle are mainly affected, and other parts and tissues of the body can also be affected. It is characterized by low muscle strength of the affected striated muscles, prone to fatigue, rapid reduction of muscle strength after repeated short-term contractions, and reduced symptoms after rest. Pediatric myasthenia gravis mainly includes 3 types: neonatal MG, congenital MG, and child MG, of which neonatal and child MG is an acquired autoimmune disease with neuromuscular junction transmission disorder, 90% of adult nicotine Type acetylcholine receptor antibody (nAChRab) is positive, nAChRab in pediatric cases is mostly negative, mainly manifested as drooping eyelids and extraocular muscle paralysis, which is more common in girls.