Thyroid hormone resistance syndrome

Thyroid hormone resistance syndrome (SRTH) is also called thyroid hormone refractory syndrome or thyroid hormone insensitivity syndrome (THIS), and was first reported by Refetoff in 1967. The disease is more common in familial diseases, and a few are sporadic cases, accounting for about 1/3. Most cases occur in children and adolescents, and the youngest are newborns, both male and female. Clinical manifestations Serum free T4 (FT4) and free T3 (FT3) continued to increase, while thyroid stimulating hormone (TSH) was normal, and the patient was not affected by drugs, non-thyroid diseases and abnormal thyroid hormone transport. The most specific manifestation is that after giving the patient a superphysiological dose of thyroid hormone, he could not inhibit the elevated TSH from falling to normal levels, and there was no response of peripheral tissues to excess thyroid hormone.