Whipple disease

It was first reported by Whipple in 1907. In 1949, Black-Schaffer stained with PAS and found PAS-positive substances in macrophages in the small intestine of patients. In 1960, Cohen et al. Studied by electron microscopy that the sickle particles in macrophages were composed of bacteria; the pathogen was rod-shaped with a width of 0.2mu; m and a length of 1.5-2.5mu; m, which is called Whipple bacilli. Pathogens invade orally and can invade various organs in the body. After long-term antibiotic treatment, patients can be cured and the bacilli gradually disappear. The disease is thought to be related to Whipple infection, but it has not been clearly identified and it has not been made into an animal model.